应该是:can you tell me 【what is the matter with】 you
be the matter with sb= be wrong with sb
也就是说,只有the matter 在be 动词后作表语时才能表示什么事不对劲, 难办,棘手, 等于 be wrong with ...
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我貌似记得高中的时候老师说过 出现matter 和 wrong时,is要在前面。应该为:can you tell me what's wrong /the matter with you ?
can u tell me what is the matter / what is wrong with you? 此处What 引导宾语从句,并充当从句主语