What's wrong with you?
What happened to you?
What's the matter with you?
What's wrong with you?
What's the problem with you?
What's the trouble with you?
What's happening to you?
What's up with you?
what is wrong with you
What happened to you?或者如果是两个人对话的，可以直接说：What happened?
What's wrong with you?
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