高分寻高手翻译!!! 在线等,急!!!有追加分!!!
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Objective : To study the excipients lactose, mannitol, beta-cyclodextrin on the stability of salicylic acid. Methods : The classic thermostats, in 50 ° C, 60 ° C, 70 ° C, 80 ° C for salicylic acid, salicylic acid + galactose, Acid + mannitol, salicylic acid + beta-cyclodextrin Thermostat, in a fixed time sampling, using UV-Vis spectrophotometer at 297 nm measured absorption, then calculated based on standard curves of the drugs salicylic acid content. From the numerical concentration of the same temperature at time t the mapping, obtained a good linear curve, with a response received a response from the regression equation can be calculated the temperature of the drug reaction rate constant k. The same drug under different temperature for a few k of the reciprocal of temperature (1 / T) mapping, derived from the linear curve well, with a dynamic formula, Reaction from a regression equation and the Arrhenius equation Stepping 25 ℃ the drug reaction rate constant, then calculated the drug t0. 9. Results : Acid t0. 9 to 28.93 days; The t0 + galactose. 9 to 14.38 days; t0 + mannitol. 9 to 26.58 days; + beta cyclodextrin t0. 9 to 47.93 days. Conclusion : lactose may accelerate the salicylic acid in aqueous solution of decomposition; Mannitol of salicylic acid in aqueous solution without the basic decomposition; beta-cyclodextrin can delay the salicylic acid in aqueous solution decomposition. Keywords : salicylic acid; Stability; Classical thermostats; Lactose; Mannitol; Beta-cyclodextrin
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英文如下:
Abstract Goal: The research supplementary material lactose, themannitol, beta - the link dextrin adds water the salicyclic acidstable influence. Method: Uses the classical constant temperature law,separately to 50 ℃, 60 ℃, 70 ℃, 80 ℃ adds water the salicyclicacid, the salicylic acid + lactose, the salicylic acid + mannitol, thesalicylic acid + beta - link dextrin constant temperature heats up, inthe fixed time sample, the use ultraviolet obviously spectrophotometerto 297nm place measured absorption, subsequently acts according to thestandard curve to extract in various drugs the salicylic acid content.The obtained density to the value to under the same temperature time tmapping, the obtained curve linearity is good, conforms to a level torespond that, by a level responded the obtained regression equationmay extract under various temperatures various drugs constant ofaction k. Under the homogeneous drugs different temperature klogarithm to the temperature reciprocal (1/T) the mapping, theobtained curve linearity is good, conforms to level of dynamicsformulas, by a level responded the regression equation and theArrhenius formula may ask 25 ℃ under various medicines the reactionrate constant, subsequently extracts various medicines t0. 9. Finally:Salicylic acid t0. 9 is 28.93 days; + Lactose t0. 9 is 14.38 days; +Mannitol t0. 9 is 26.58 days; + beta Link dextrin t0. 9 is 47.93 days.Conclusion: The lactose may accelerate the salicylic acid in waterysolution decomposition; The mannitol adds water the salicyclic acidbasically not to have the influence in watery solution decomposition;Beta - The link dextrin may delay the salicylic acid in waterysolution decomposition. Key word: Salicylic acid; Stability; Classical constant temperaturelaw; Lactose; Mannitol; Beta - Link dextrin
摘要
目的:研究辅料乳糖、甘露醇、β-环糊精对水杨酸稳定性的影响。方法:采用经典恒温法,分别于50℃、60℃、70℃、80℃对水杨酸、水杨酸+乳糖、水杨酸+甘露醇、水杨酸+β-环糊精恒温加热,在固定时间取样,利用紫外可见分光光度计于297nm处测吸收度,继而根据标准曲线求出各药品中水杨酸含量。所得浓度的对数值对相同温度下的时间t作图,所得曲线线性良好,符合一级反应,由一级反应所得回归方程可求出各温度下各药品的反应速率常数k。同种药品不同温度下的k的对数对温度的倒数(1/T)作图,所得曲线线性良好,符合一级动力学公式,由一级反应回归方程及Arrhenius公式可求25℃下各药的反应速度常数,继而求出各药的t0。9。结果:水杨酸的t0。9为28.93天;+乳糖的t0。9为14.38天;+甘露醇的t0。9为26.58天;+β环糊精的t0。9为47.93天。结论:乳糖可加速水杨酸在水溶液中的分解;甘露醇对水杨酸在水溶液中的分解基本无影响;β-环糊精可延缓水杨酸在水溶液中的分解。
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