楼主理解的很好，despite是介词，不能跟that从句，但可以跟despite the fact that
根据牛津的解释：given是介词，跟名词；given that相当于连词，自然可以跟从句了
牛津原文是：given that： conjunction: e.g.： It was surprising the government was re-elected, given that they had raised taxes so much.
介词后面是可以跟从句的, 如despite that, in that......
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