推荐回答(1个)
药物过敏性休克是药物过敏的一种严重反应,以注射青霉素等抗生素时发病者最多,快者发生在注射针头尚未拨出或在作皮试时,大多数发生在给药5分钟至半小时内。先是面红、胸闷、气紧、头晕、心悸、四肢发麻,继之面色苍白或发绀、出冷汗、四肢厥冷、脉搏细弱、血压下降、神志不清乃至昏迷,有的可同时伴有荨麻疹、血管性水肿等皮肤过敏反应。
休克一旦发生,应立即抢救:立即将0.1%肾上腺素0.5~1毫升肌注或加入50%葡萄糖液40毫升内静注,以升高血压,当收缩压低于80毫米汞柱时应加升压药;立即静滴氢化考的松200~400毫克;心跳骤停时,左心室内注射0.1%肾上腺素0.5毫升,并做人工呼吸;喉头水肿时应吸氧、气管切开;支气管痉挛严重者可静注0.25克氨茶碱。
药物过敏性皮炎也是药物过敏的一种常见反应,一般突然发生于治疗过程中,出现全身性对称分布的皮疹伴瘙痒。其特点为:只发生于少数有特异过敏体质的服药者,对大多数人不发生反应;皮疹与药物性质及药量无关,多为正常量或小剂量引发;有潜伏期,多发生在首次用药后的7~10天,或再次用药后的数小时或2日内;皮疹形态各异,同种药物同一个人在不同时期可发生相同或不同型药疹;药疹治愈后,再用与原来过敏药物结构相似的药物,出现交叉过敏,甚至在药疹高潮时,对不同结构的药物出现多价过敏;抗过敏药物治疗有效。
药疹的皮肤表现可归纳为如下5型:固定型药疹:多为发生在皮肤粘膜交界处的圆形或椭圆形水肿性红斑,界限清楚,其上有水疱或大疱,伴有瘙痒。停药1~2周后红斑消退,留有黑色素沉着斑,如再服该药,除在原部分复发皮疹外,其它处亦有新疹出现。病程往往较长。
荨麻疹及血管性水肿型:起病急,常先觉皮肤瘙痒,继而出现形态不一、大小不等的鲜红色风团或苍白色风团,表面毛孔显著如桔皮样,损害约经10分钟至数小时后消退,不留痕迹,但此起彼伏,一日内发作数次,严重者伴有过敏性休克及呼吸道、消化道粘膜受累的症状,有现为恶心、呕吐、复痛、腹泻、喉头发痒、呼吸困难、窒自己甚至血压下降。一般经数日或1~2周而愈。
猩红热样或麻疹样发疹型:是药疹中最常见的一种,弥漫性鲜红色斑或半米粒大至豆大红色斑丘疹,密集对称分布,形态如猩红热样或麻疹样,有时上述两种皮疹可在同一患者身上同时出现。一般在停药两周后完全消退。
紫癜型药疹:为针头大至豆大或更大的出血性紫斑,皮疹平或稍隆起,轻者出现在双小腿,重者累及四肢躯干。这种发疹没有血小板减少。
大疱性表皮松懈萎缩坏死型:是药疹最严重的一型。发病急,初起为面、颈、前胸部的深红或暗红斑,很快融合成片,发展至全身,斑上有大小不等的水疱,可用手指推动,稍用力表皮即可擦掉,如烫伤样表现,粘膜亦有大片坏死剥脱。全身中毒症状严重,伴有高热和内脏病变,如果抢救不及时,可死于感染、毒血症、肾衰、肺炎或出血。
其他型药疹:有湿疹型药疹、多形红斑型药疹、剥脱皮炎型药疹、痤疮样药疹、光感性药疹等,其临床表现同相应疾病。
药疹的诊断主要是根据病史及临床表现,除固定型药疹具有特征性表现之外,多数药疹不易与其它原因引起的同样症状相区别,必须根据病史及发展过程加以综合分析而作出诊断。
发生药疹后应停用一切可疑致敏药物及结构近似的药物,鼓励多饮水。轻型药疹一般予以抗组织胺药及维生素C,必要时强的松30~60毫克/日,口服,待皮疹消退后逐渐减量以至停药;局部用水剂、粉剂,有糜烂渗出时用湿敷。重症药疹应及早用皮质类固醇激素静滴,一般给氢化考的松200~400毫克,地塞米松16毫克/日;加强支持疗法:注意水、电解质平衡;预防支气管肺炎或皮肤化脓感染,有败血症时应选用有效抗生素注意防治合并症:如肝肾损害应对症治疗;眼及口腔粘膜损害时,用抗生素及氢考眼药水(膏)及1/8000高锰酸钾液漱口;局部可对症用不同的外用药。
药疹多为医源性,因此必须注意:用药前询问病人过敏史,避免使用已知过敏或结构相似的药物;用药应有的放矢,可用可不用的药尽量不用,用药过程中应注意药疹的早期症状,如发现应立即停药;应用青霉素、血清、普鲁卡因等药物时,应按规定方法作皮试,阳性者不用该药。皮试时应备有急救药物,以应急用已确诊为药疹者,应嘱病人牢记致敏药物,每次看病时告诉医生勿用此药。
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