叔叔可能得了胆管癌,请问胆管癌怎么确诊?那儿治疗的比较好?
推荐回答(2个)
实验室检查:主要表现为梗阻性黄疸的肝功能异常,如胆红素和碱性磷酸酶的增高等。
磁共振成像对胆管癌的诊断价值
胆管癌在临床上并不少见,其病因至今未明,临床诊断亦较困难,多出现阻塞性黄疸后才确诊。目前,胆管癌的诊断和外科手术治疗比过去有了长足的进步〔1〕。随着医学影像学的发展,磁共振成像(MRI)以其无创伤、分辨率高的特性对胆管癌诊断的价值和术前评价日益受到重视。本文通过回顾性分析来探讨胆管癌在MRI的征象,以期进一步提高MRI对胆管癌的诊断。
1 资料与方法
1.1 一般资料 收集我院2005年1月~2006年2月经手术和病理证实为胆管癌的患者62例。男35例,女27例,年龄37~84岁,平均60.5岁。
1.2 方法 全部患者均行MRI扫描。使用SIEMENS Sonota 1.5T磁共振扫描仪。检查前空腹8~12h。扫描序列:平扫横断位采用快速小角度激发成像序列(FLASH)T1WI加脂肪抑制(FS)和半傅立叶采集单次激发快速自旋回波序列(HASTE)T2WI;冠状位采用真正稳态下的快速成像(TRUFI)T2WI,所用参数:FOV 330×380;矩阵256×512;层厚8.0mm;层距因子20%;翻转角80°;平扫后做增强扫描(T1WI+FS)。扫描方位:常规行横断面扫描,辅以冠状及矢状面扫描,所用对比剂为Gd-DTPA''剂量20ml,从肘静脉快速推注,注射速度2ml/s。磁共振胰胆管造影术(MRCP)采用2D厚重T2WI,TR/TE 4500/980,FOV 400×400。
2 结果
2.1 胆管癌部位 肝内胆管细胞癌11例;肝门胆管细胞癌16例;肝外胆管细胞癌35例。
2.2 肝内胆管癌MRI和MRCP表现 左肝7例,右肝4例。均为不规则形的肝内局部异常信号,T1WI呈稍低混杂信号,囊变坏死呈低信号,中间夹杂有扩张的小胆管或者黏液湖呈更低信号。T2WI呈稍高混杂信号,实质部呈稍高信号,中间夹杂有扩张的小胆管或者黏液湖呈更高信号。可见病灶周围扩张的小胆管6例。可见病灶坏死或者囊变5例。增强扫描病灶动脉期强化不明显5例,静脉期病灶的实质呈斑片状不规则轻度强化7例,中度强化3例;延时后强化3例。MRCP可见病灶区胆管走向杂乱、僵直、各种形状的截断狭窄及病灶周围的小胆管扩张,其中周围胆管扩张7例,病灶较大致肝门区胆管截断性狭窄3例。合并胆道系统结石4例,5例病灶附近呈现肝萎缩。2例胆囊受累,3例肝右后叶淋巴结转移,1例腹膜系膜受累及腹膜后淋巴结转移,1例胃窦部受累(图1)。
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参考资料:http://med.511511.com/press/20068/clinic108570.shtml
MRCP磁共振胰胆管水成像,可以帮助诊断。我只能说有帮助,什么检查都不能打包票,除非病理活检。
但以我的经验,一般做了MRCP就差不多能诊断了。
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