accuse意为“控告，谴责”，一般搭配为accuse sb. of sth.
（表过失或罪行的词）。
His assistant was accused of theft and fraud by the police
He was accusing her of having an affair with another man.
prosecute意为“对……起诉，告发”，一般搭配为prosecute sb. for sth.
He is being prosecuted for two criminal offences.
反义：defend
补充：charge意为“控诉，指责”，一般搭配为charge sb. with sth.
（表做错或罪行的词）。
The police have charged him with rape.
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