不是。关键还看句中的意思，any这里就表示“任何”。
If you have any quentions, please let me know.
如果你有任何问题，请让我知道。
Just let me know if you need any help。
.Put up your hands if you have any questions
Please give me some gasoline if you have any
If this is coffee, please bring me some tea; but if this is tea, please bring me some coffee.
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