Results of 1327 sputum specimens of 303 strains with klebsiella pneumoniae was isolated, the detection rate of 22.8%, which produce the ultra broad spectrum beta lactamase (ESBLs) have 137 strains, accounting for 45.2%. Producing ESBLs class 100% resistant bacteria pneumonia klebsiella penicillin, cephalosporin more than 78.8% of the drug resistance, and in the majority with in, and aminoglycoside resistance in producing ESBLs pneumonia klebsiella bacteria are the lowest amikacin, accounted for 31.4%. The beta lactamase inhibitor was 35.1% - 43.8%, if sinensis ketone resistant rate accounted for 46.7%.