什么是神经毒素、细胞毒素、心脏毒素、出血毒素、溶血毒素、肌肉毒素、坏死毒素

它们的作用机理是什么?会损伤哪种细胞?中毒时的表现?谢谢
2025-02-23 00:49:41
推荐回答(2个)
回答1:

动物毒素绝大多数是蛋白质。大多是在有毒动物的毒腺中制造并以毒液的形式经毒牙或毒刺注入其他动物体内。纯的毒素根据生物效应,可分为神经毒素、细胞毒素、心脏毒素、出血毒素、溶血毒素、肌肉毒素或坏死毒素等。 神经毒素又称神经毒。对神经组织有毒性或破坏性的内毒素,可使周围神经有髓鞘、脑和脊髓及其他组织产生脂肪性变。多为天然存在,如蛇毒、蝎毒、峰毒等动物毒素、植物毒素、海洋毒素、微生物毒素中含有神经毒素。常可引起神经毒素(如蛇毒)和突触前神经毒素。也有作用于神经轴突(如石房蛤毒素),中枢神经系统的(如某些蕈毒素)。 主要是指作用于离子通道的毒素。 细胞毒素对特定的细胞造成毒性作用的能力或趋势。可对细胞造成损伤或死亡。 溶血毒素,许多病原微生物所产生的,能导致机体红细胞及其他有核细胞裂解的毒素类物质。多数是由革兰氏阳性菌所产生。能产生溶血毒素的细菌,在血平板上生长时常可形成清晰的溶血环,环的直径与该菌在生长过程中所产生的毒素的量成正比。溶血毒素的主要作用部位是敏感细胞的细胞膜脂质部分。 ①神经毒素,作用于神经-肌肉接头,阻断兴奋的传递。中毒者常死于呼吸肌麻痹引起的呼吸衰竭。由于这些毒素是大分子蛋白质,不能通过血脑屏障进入脑内,对中枢神经系统无作用,只作用于外周神经系统。按作用部位通常分为:突触前神经毒素和突触后神经毒素。前者作用于神经末梢,抑制神经递质──乙酰胆碱的释放,突触前毒素都具磷酯酶A2活性,当酶活性丧失,毒性也就随之消失。后者作用于突触后膜。已发现的突触后毒素近百种,主要存在于眼镜蛇科和海蛇科蛇毒中。②心脏毒素,是由60~62个氨基酸组成的分子量较小的强碱性蛋白质。一级结构与突触后神经毒素的短毒素相似。心脏毒素能溶解细胞,又称细胞毒素。③出血毒素,从蛇毒中分离出的出血毒素是分子量在30000~40000的蛋白质,具蛋白水解酶活性,含金属离子,属于金属蛋白酶类。出血毒素作用于毛细血管壁,引起血管破裂,导致局部或全身出血症状。④溶血毒素,也称做溶血因子,是一种由57个氨基酸组成的分子量为7000的碱性蛋白质,能破坏红细胞膜而致溶血。另外蛇毒中的磷酯酶A2,能水解卵磷酯生成溶血卵磷酯,也能溶血,称为间接溶血因子。⑤肌肉毒素或肌肉坏死毒素,如中国的尖吻蝮蛇毒能引起严重的肌肉坏死,咬伤后常导致截肢残废。美洲的响尾蛇毒也可造成类似的症状,从该蛇毒中提纯的肌肉毒素,是一种38个氨基酸组成的多肽,另外还有分子量较大的肌肉毒素,尚未纯化。

回答2:

科技名词定义 中文名称:神经毒素 英文名称:neurotoxin 定义1:能引起昆虫神经极度兴奋的毒剂。 所属学科: 昆虫学(一级学科) ;昆虫毒理与药理(二级学科) 定义2:对神经组织具有毒性或破坏作用的毒素。尤其是肉毒杆菌、破伤风杆菌、白喉杆菌和志贺痢疾杆菌等的外毒素。 所属学科:

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