. 我感觉很难过。都是我不好。
I feel terrible. It was all my fault.
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2. 听说您今天感觉不舒服,我很难过。
I'm sorry to hear you are not feeling well today.
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I feel very upset/depressed或I am low.
比较地道的说发就是
i feel very sad!
I feel very sad.
I feel so depressed
I feel as if the world came to an end