that is可不可以搭配because

这个是可以的。就是一个由because引导的表语从句。
例如：
1.That is because it is raining outside.那是因为外面正在下雨。
2.That is because he said so yesterday. 那是因为他昨天是这样说的。
拓展：
that is why 、 that is because 区别
that is why后面跟的是结果,译为：“那是（为什么）...... 的原因”
例如：
Tom overslept this morning. That is why he was late for work.
汤姆今天早晨睡过头了。那是他上班迟到的原因。
that is because后面跟的是原因，译为：“那是因为.......”
例如：
Tom was late for work this morning. That is because he overslept.
汤姆今天早晨上班迟到了。那是因为他睡过头了。

可以的。例如：
That is because the poet wishes to remind us how much a year canchange a person when he or she is young.
那是因为诗人希望提醒我们，当一个人年少时，短短一年可以使他或她有多大的改变。
He did not see the film last night. That is because he had to help his little sister with her homework.
昨天晚上他没有去看电影。那是因为他得帮他的妹妹做作业。
That is because in a boring summer of tennis and a World Cup that mostAmericans care little about, LeBron is all that matters.
那是因为在一个无聊的网球和世界杯的夏天，大多的美国人并不在乎那些，这就是因为猩猩。

仅供参考，谢谢欣赏