You must have had a hard time so please have a good rest! (若是说做了什么事情费了一些周折，故而称之为辛苦的话)
You must have had a long day/flight so please have a good rest! (若是旅途劳顿引起的辛苦的话)
you must be tired,please have a rest!
You must be tired and have a good rest.
You must be very tired, please have a good rest!
you must feel very tired.Have a good rest.
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