推荐回答(2个)
第一类有机溶剂
是指已知可以致癌并被强烈怀疑对人和环境有害的溶剂。在可能的情况下,应避免使用这类
溶剂。如果在生产治疗价值较大的药品时不可避免地使用了这类溶剂,除非能证明其合理性,
残留量必须控制在规定的范围内,如:
苯(2ppm)、四氯化碳(4ppm)、1,2-二氯乙烷(5ppm)、1,1-二氯乙烷(8ppm)、1,1,1-三氯乙烷(1500ppm)。
第二类有机溶剂
是指无基因毒性但有动物致癌性的溶剂。按每日用药10克计算的每日允许接触量如下:
2-甲氧基乙醇(50ppm)、氯仿(60ppm)、1,1,2-三氯乙烯(80ppm)、1,2-二氧基乙烷(100ppm)、1,2,3,4-四氢化萘(100ppm)、2-乙氧基乙醇(160ppm)、环丁砜(160ppm)、嘧啶(200ppm)、甲酰胺(220ppm
)、正己烷(290ppm)、氯苯(360ppm)、二氧杂环己烷(380ppm)、乙腈(410ppm
)、二氯甲烷(600ppm)、乙烯基乙二醇(620ppm)、N,N-二甲基甲酰胺(880ppm)、甲苯(890ppm)、N,N-二甲基乙酰胺(1090ppm)、甲基环己烷(1180ppm)、1,2-二氯乙烯(1870ppm)、二甲苯(2170ppm)、甲醇(3000ppm
)、环己烷(3880ppm)、N-甲基吡咯烷酮(4840ppm)、。
第三类有机溶剂
是指对人体低毒的溶剂。
急性或短期研究显示,
这些溶剂毒性较低,
基因毒性研究结果呈阴
性,
但尚无这些溶剂的长期毒性或致癌性的数据。
在无需论证的情况下,
残留溶剂的量不高
于
0.5
%是可接受的,但高于此值则须证明其合理性。这类溶剂包括:
戊烷、甲酸、乙酸、乙醚、丙酮、苯甲醚、1-丙醇、2-丙醇、1-丁醇、2-丁醇、戊醇、
乙醇、乙酸丁酯、三丁甲基乙醚、乙酸异丙酯、甲乙酮、二甲亚砜、异丙基苯、乙酸乙酯、
甲酸乙酯、乙酸异丁酯、乙酸甲酯、3-甲基-1-丁醇、甲基异丁酮
除上述这三类溶剂外,在药物、辅料和药品生产过程中还常用其他溶剂,如
1,1-二乙氧基丙烷、1,1-二甲氧基甲烷、2,2-二甲氧基丙烷、异辛烷、异丙醚、甲基异丙酮、甲基四氢呋喃、石油醚、三氯乙酸、三氟乙酸。这些溶剂尚无基于每日允许剂量的毒理学资料,
如需在生产中使用这些溶剂,必须证明其合理性
1、按沸点高低的分类
(1)低沸点溶剂(沸点在100度以下)这类溶剂的特点是蒸发速度快,易干燥、粘度低,大多数具有芳香气味.属于这类溶剂的一般是活性溶剂或稀释剂.例如:甲醚、甲酸甲酯、丙酮、苯等等
(2)中沸点溶剂(沸点在100~150度)这类溶剂用于硝基喷漆,流平性好.例如:丁醇、甲苯、环己酮等等
(3)高沸点溶剂(沸点在150~200度)这类溶剂的特点是蒸发速度慢,溶解能力强,作涂料用时涂膜流动性好,可以防止沉淀合涂膜发白.例如:乳酸乙酯、糠醇等
(4)增塑剂合软化剂(沸点在300度左右)这类溶剂的特点是形成的薄膜粘度强合韧性好.例如:硝化纤维素用的樟脑
2、按蒸发速度分类
(1)快速蒸发溶剂 蒸发速度为乙酸丁酯的3倍以上者
(2)中速蒸发溶剂 蒸发速度为乙酸丁酯的1.5倍以上者
(3)慢速蒸发溶剂 蒸发速度比工业戊醇快,比乙酸仲丁酯慢
(4)特慢蒸发溶剂 蒸发速度比比工业戊醇慢
3、按极性分类
(1)极性溶剂
(2)非极性溶剂
4、按化学组成分类
(1)有机溶剂
(2)无机溶剂
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