In reality, e-learning, the teaching content more abstract and difficult to understand, plus the lack of effective convergence programs, as well as lack of laboratory equipment, so that students can not go to make full use of laboratory equipment. And traditional small and experimental box format, so that schools lack teaching SCM software platform, resulting in a comprehensive experiment teaching, lack of innovation and experimental methods, it is difficult train large numbers of qualified talents. According to the actual teaching situation so Binzhou College, interrupt Simulation Based Design Proteus of ARM. This design is mainly designed Eint1 external interrupt, multiple external interrupts, timers ARM-based Proteus simulation, and also designed a comprehensive simulation of fuzzy control system based on LPC2124 temperature. The completion of the design cases to other comprehensive design part of the need to interrupt the foundation, can be used directly as a number of interrupt simulation module design part of the case is filled with teaching and basic teaching content.