(x-5y)(-x-5y)-(-x+5y)2=-(x2-25y2)-(x2-10xy+25y2)=-x2+25y2-x2+10xy-25y2=(-1-1)x2+(25-25)y2+10xy=-2x2+10xy,∵x=-1,y=0.5,∴上式=-2×(-1)2+10×(-1)×0.5=-2-5=-7.