什么使你的朋友如此与众不同?
What makes your friend so different(special)?
make sb. sth. 使某人怎么样
What makes your friends so different/special/unique(独特的，我比较赞成）
What make your friend so different?
what makes your friends so pecial?
What makes your friend so unique?
相比之下，Unique比较符合点。
What makes your friends so unique
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